Cajun Chicken Alfredo
216 CommentsUpdated Jan 28, 2026
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Creamy cajun chicken fettuccine alfredo is a perfect meal for any weeknight. You can make a homemade Cajun alfredo sauce and tender chicken in the slow cooker, then add cooked fettuccine noodles to complete the dish.
Featured Comment
This was absolutely perfect ❤️ I made it for the first time yesterday ! My son is raving over it. We are just two so want to have it again tonight.
– pam
Cajun chicken pasta is a great spicy recipe for pasta night! This pasta has a bit of a kick to it, mainly from the cayenne. It was a nice change from my regular pasta recipes. My recipe is from scratch – no jarred Alfredo. Has just the right amount of heat and creaminess. The slow cooker makes great southern meals, also try my new recipe for Swamp Potatoes.
Key Ingredients
- Chicken – Use boneless skinless chicken breasts for this dish. They shred up perfectly.
- Seasonings – Make a homemade cajun seasoning blend with cayenne pepper, red pepper flakes, oregano, onion powder, garlic powder, paprika, salt, and pepper. You can add more cayenne pepper for a bolder cajun flavor.
- Chicken broth – This is the base of the sauce and will help keep chicken breast moist during the cooking process.
- Heavy Cream – Makes the dish creamy and helps thicken it, don’t use half and half or milk.
- Parmesan Cheese – This adds flavor to the creamy alfredo sauce. You can use shredded parmesan cheese or grated parmesan cheese.
- Fettuccine Noodles – A classic noodle for cajun chicken pasta.
How to Make Cajun Chicken Alfredo
- Cook the chicken in seasoned broth until tender.
- Shred the chicken, then stir in cream, parmesan, and cooked pasta.
- Let it warm through until the sauce thickens and everything is well combined.
Tips & Variations
Shrimp – Add shrimp 15 minutes before the cooking time is done. Shred the chicken, add the cream and noodles and cook for the 20 additional minutes still. Make sure the shrimp is cooked through.
Andouille sausage – You can add one pound of sliced andouille sausage at the beginning of the cooking time.
Pasta Swap – You can use penne pasta instead of fettuccine noodles for a heartier noodle.
Add Veggies: To make this a complete meal, add steamed broccoli or frozen peas to the pasta just before serving.
Cream Swap: You can add a block of cream cheese to this dish instead of heavy cream. You can add it at the beginning of the cooking time, or microwave it for 30 seconds before adding the dish at the end of the cooking time.
Cajun Seasoning: You can use two teaspoons of cajun spice seasoning (such as Tony’s Chachere’s Creole Seasoning) instead of the different seasonings in this dish. Don’t add any more, for it can be on the salty side.
Why isn’t my Pasta Spicy?
Cayenne pepper loses its potency the longer it’s been on the shelf, or it may not be as spicy as other brands. You can add additional cayenne pepper after the dish is done cooking for more Cajun spice.
Cajun Chicken Alfredo Recipe
How to Video
Ingredients
- 1 cup chicken broth
- 1/4 tsp. cayenne pepper
- 1/2 tsp. garlic powder
- 1/4 tsp. onion powder
- 1/2 tsp. dried leaf oregano
- 1/4 tsp. red pepper flakes
- 1 1/2 tsp. paprika
- 1 tsp. salt
- 1/4 tsp. pepper
- 2 lbs. boneless skinless chicken breasts
- 1 small white onion, diced
Add at the end:
- 1 lb. fettuccine noodles, cooked according to package directions
- 2 cups heavy cream
- 3/4 cup parmesan cheese, divided
- dried parsley or oregano for garnish
- paprika for garnish
Instructions
- Add the chicken broth to the slow cooker, add the cayenne, garlic powder, onion powder, oregano, red pepper flakes, paprika, salt and pepper. Stir.
- Add the chicken breasts and flip them around in the seasoned chicken broth to get the seasonings on the chicken.
- Sprinkle the onions over the chicken and broth.
- Cover and cook on low for 6 hours without opening the lid during the cooking time.
- After the cooking time is done, shred the chicken with two forks right in the slow cooker. Add the heavy cream.
- Add the cooked and drained pasta and a ½ cup of the Parmesan cheese. Stir.
- Sprinkle over the remaining parmesan cheese. I added a touch more paprika and also parsley flakes to the top of my pasta to make it look pretty. Cover and cook for 20 more minutes. Cooking for a bit longer helps the sauce thicken from the gluten in the pasta.
- Serve and enjoy!
Nutrition
Nutrition info is auto-generated. This information is an estimate; if you are on a special diet, please use your own calculations.
More Slow Cooker Pasta Recipes
Slow Cooker Baked Spaghetti and Salsa Ranch Chicken Pasta are flavorful, no-fuss dinners the whole family will love.
Garlic Butter Pasta and Pesto Mozzarella Chicken Pasta bring bold, comforting flavor with simple ingredients.
Crockpot Chicken Alfredo and Slow Cooker Carbonara are creamy slow cooker classics perfect for cozy nights in.
When you add the cream at the end it just stays watery. If you add a little water and corn starch slurry after you add the cream and let it stay on warm for a bit it will be much much better, thicker and give the noodles a chance to absorb the flavors 🙂
You can add the cornstarch to the cream too!
Could I use chicken thighs instead of breasts
Yes, chicken thighs work great in this recipe.
Very tasty! Wish the spice soaked into the noodles more but definitely a kick with the bites of chicken! I was worried seeing all the reviews about watery sauce. I’m wondering if people didn’t use the whole lb of noodles or didn’t cook the extra 20? It came out just fine for us ! Super easy and yummy! Wish it was a little more creamy but other than that, definitely would make again!
Figured I would try this for dinner since I like trying new things and love Cajun seasoning. My sauce was just liquid and never thickened. Followed the directions to a T and it was still pretty bland. My husband didn’t even like it. I used cayenne pepper that I had just opened and even added extra. He asked me not to make it again.
Can the left overs be frozen?
Yes!
Did not get a creamy sauce. The cheese kinda all stuck to the chicken and it was just like a watery soup on the bottom. Teach good but I wish I would’ve had a nice creamy pasta dish.
I love pasta (too much) and I am hungry. This has made me hungrier!
Thanks!
Had really high hopes for this but the sauce js just like water and does not coat the noodles at all 🙁
My sauce was soup too. Is there something that can be added to thicken?
You can make a cornstarch slurry. 2 tablespoons of cold water mixed with 2 tablespoons cornstarch. Add it and put the lid back on. Takes about 15 minutes to thicken.
It was alright.
I like it in the crock pot but has anyone tried it in an Instapot? Don’t use smoked paprika it was gross, lol my mistake.